Familial Sex Reversal: A Review
نویسندگان
چکیده
منابع مشابه
A novel germ line mutation in SOX9 causes familial campomelic dysplasia and sex reversal.
Mutations in the gene SOX9 result in the syndrome of campomelic dysplasia (CD) which includes sex-reversal in 75% of 46,XY affected individuals. These mutations only affect a single allele of SOX9 suggesting a dominant mode of inheritance for this syndrome. Consequently, CD and autosomal sex reversal may result from haploinsufficiency of SOX9. The SOX9 gene maps to the long arm of human chromos...
متن کاملSex Reversal in Amphibians.
Amphibians have been widely used to study developmental biology due to the fact that embryo development takes place independently of the maternal organism and that observations and experimental approaches are easy. Some amphibians like Xenopus became model organisms in this field. In the first part of this article, the differentiation of the gonads in amphibians and the mechanisms governing thi...
متن کاملSex Reversal in Birds.
Sexual differentiation in birds is controlled genetically as in mammals, although the sex chromosomes are different. Males have a ZZ sex chromosome constitution, while females are ZW. Gene(s) on the sex chromosomes must initiate gonadal sex differentiation during embryonic life, inducing paired testes in ZZ individuals and unilateral ovaries in ZW individuals. The traditional view of avian sexu...
متن کاملTemperature sex reversal implies sex gene dosage in a reptile.
Sex in reptiles is determined by genes on sex chromosomes or by incubation temperature. Previously these two modes were thought to be distinct, yet we show that high incubation temperatures reverse genotypic males (ZZ) to phenotypic females in a lizard with ZZ and ZW sex chromosomes. Thus, the W chromosome is not necessary for female differentiation. Sex determination is probably via a dosage-s...
متن کاملHormonal sex reversal in a female.
The terms pseudo-hermaphroditism and hermaphroditism have been used in different senses by various authors and for this reason they were discarded by Wilkins (1950). He describes as 'intersexes' (hermaphrodites) those cases in which the sexual dimorphism is not due to a demonstrable endocrine abnormality, and as cases of 'sex reversal' those in which there is an endocrine abnormality. Hormonal ...
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ژورنال
عنوان ژورنال: Journal of Clinical Endocrinology & Metabolism
سال: 2000
ISSN: 0021-972X
DOI: 10.1210/jc.85.2.483